Mechanically and visually imperceptible sensor sheets integrated with light-weight wireless loggers are employed in ultimate flexible hybrid electronics (FHE) to reduce vital stress/nervousness and monitor natural biosignal responses. The key technologies and applications for conceptual sensor system fabrication are reported, as exemplified by the use of a stretchable sensor sheet completely conforming to an individual’s body surface to realize a low-noise wireless monitoring system (<1 μV) that can be attached to the human forehead for recording electroencephalograms. The above system  can discriminate between Alzheimer’s disease and the healthy state, thus  offering a rapid in-home brain diagnosis possibility. Moreover, the introduc-tion of metal nanowires to improve the transparency of the biocompatible  sensor sheet allows one to wirelessly acquire electrocorticograms of non-human primates and simultaneously offers optogenetic stimulation such as toward-the-brain–machine interface under free movement. Also discussed are effective methods of improving electrical reliability, biocompatibility, minia-turization, etc., for metal nanowire based tracks and exploring the use of an organic amplifier as an important component to realize a flexible active probe with a high signal-to-noise ratio. Overall, ultimate FHE technologies are  demonstrated to achieve efficient closed-loop systems for healthcare  management, medical diagnostics, and preclinical studies in neuroscience and neuroengineering

原文：https://onlinelibrary.wiley.com/doi/pdf/10.1002/adma.201902684